Question

Different steps of the oxidative decarboxylation of pyruvate by the pyruvate dehydrogenase pdh complex are given. Place these five steps in the correct order. Note that thiamine pyrophosphate, tpp , is sometimes called thiamine diphosphate, tdp.

Answer 1

Different steps of the oxidative decarboxylation of pyruvate by the pyruvate dehydrogenase pdh complex are given by placing them in the order as followed.

What is Oxidative decarboxylation?

The Oxidative decarboxylation reactions are oxidation reactions wherein a carboxylate institution is removed, forming carbon dioxide. They regularly arise in organic systems: there are numerous examples withinside the citric acid cycle. This sort of response probable began out early on the starting place of life.

1. Pyruvate reacts with TPP and is decarboxylated, forming hydroxyethyl-TPP.
2. The lipoamide arm movements to the energetic E underline three in which the decreased lipoamide is oxidized through FAD, forming the energetic lipoamide and triangle down ADH2 .
3. ADH_ is reoxidized to FAD, lowering NAD to NADH.every so often known as thiamine.
4. The acetyl lipoamide arm of E_ movements to the energetic of E_ , in which the acetyl institution is transferred to CoA forming acetyl-CoA and the decreased shape of lipoamide.

Read more about the lipoamide:

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