Question

In the reaction catalyzed by the pyruvate dehydrogenase complex, the two carbons constituting the acetyl group are

Answer 1

Transferred to the lipoamide by an earlier intermediate in the process.

The pyruvate dehydrogenase complex (PDC) is a mitochondrial multienzyme complex composed of three different enzymes

What reaction is catalyzed by enzyme 2 of the pyruvate dehydrogenase complex ?

the pyruvate dehydrogenase complex is the bridge between glycolysis and the citric acid cycle

• Five coenzymes are used in the pyruvate dehydrogenase complex reactions: thiamine pyrophosphate or TPP, flavin adenine dinucleotide or FAD, coenzyme A or CoA, nicotinamide adenine dinucleotide or NAD, and lipoic acid.
• during the reactions catalyzed by the pyruvate dehydrogenase complex, it is first reduced to dihydrolipoamide, a dithiol or the reduced form of the prosthetic group, and then, reoxidized to the cyclic form.

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