Question

Drugs to treat systemic fungal infections can be toxic to the host and are not used indiscriminately. Which are factors considered before an antifungal is prescribed

Answer 1

Factors considered before an antifungal is prescribed to treat systemic fungal infections are:

• Checking previous allergic conditions which can affect the treatment.
• Possible side-effects of the drug.
• Can antifungal medicine may interact with other medicines a patient is taking.
• Checking pregnancy conditions because they may affect the fetus or breastfeeding.

Systemic fungal infections are defined as invasive fungal infections which originate at a particular place in the body but have the ability to spread to other parts as well. Examples are aspergillosis and other mold infections as a result of inhalation; candidaemia as a result of infected lines or leakage from the gastrointestinal tract.

Improper medication for systemic fungal infections can lead to Infusion-related toxicity, Nephrotoxicity, including hypokalemia, liver function abnormalities, skin rash, visual disturbances, etc.

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