To find the functional connection's purpose in <em>A. thaliana's</em> chromatin, transcription, and splicing. It was studied and evaluated with the RNAPII processivity (involvement of TFIIS), chromatin structure (roles of BRM, SWI3c, and H1.3 in AS), and spliceosome formation were all investigated at three separate levels (characterization of the role of spliceosome disassembly factor NTR1 in the selection of splice sites).
The alteration of RNAPII elongation rate as the mechanism for NTR1 and TFIIS influences splicing.
Lack of NTR1 causes both localized lower RNAPII levels at those splice locations as well as defective splicing. This can be translated as quicker transcription elongation over those sites in accordance with the kinetic concept of transcription/splicing coupling.
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