Question

Compared to humans, elephants have a dramatically low instance of cancer. Elephants have multiple copies of the

Answer 1

Elephants have multiple copies of the p53 genes that play an important role in the control of cell division.

What is the role of p53 genes in elephants?

P53 is an important regulator of the DNA repair processes and controls uncontrolled cell proliferation. When DNA is harmed, the protein becomes active and aids in orchestrating a response that stops DNA replication and fixes any incorrect copies of the cell. The oncogene MDM2 E3 ubiquitin ligase, another protein, is responsible for deactivating the p53 repair activity in duplicated cells with intact DNA since it is not required.

A human with only two alleles from a single gene has much fewer molecular anti-cancer interactions than an elephant, which has 40 alleles, or versions, from its twenty p53 genes. Although the elephant may appear to have excessive genetic diversity, each of its 40 alleles is structurally slightly different.

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Compared to humans, elephants have a dramatically low instance of cancer. Elephants have multiple copies of the _____ genes that play an important role in the control of cell division.

Learn more about p53 genes here:

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