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Reil [10]
2 years ago
9

Transcriptomic profiling identifies an exosomal microRNA signature for predicting recurrence following surgery in patients with

pancreatic ductal adenocarcinoma
Biology
1 answer:
svetlana [45]2 years ago
8 0

In order to create an exosomes miRNA panel for predicting recurrence after surgery in patients with PDAC, we undertook genome-wide expression profiling.

Offering patients with pancreatic ductal adenocarcinoma (PDAC) personalized therapy requires pre-treatment risk classification, yet it is still difficult to predict recurrence after surgery.210 plasma and serum samples from four cohorts of PDAC patients were examined. We carried out genome-wide sequencing on a discovery cohort (n = 25) to find potential exosomes miRNAs (exo-miRNAs). Then, using two clinical cohorts without neoadjuvant therapy (NAT) (training cohort: 82, validation cohort: 57) and a post-NAT clinical cohort (n =46), we trained and validated the exo-miRNAs' predictive performance.

Learn more about  surgery in patients with PDAC here.

brainly.com/question/28209300

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