Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
Answer:
Cancer cells dont stop growing, normal cells stop growing,
Cancer cells dont not interact with other cells but a normal cell interacts with other cells
Cancer cells do not make any substances to make the cell sticky, Normal cells do create these types of substances.
Explanation:
Answer:
im not an army
but ill still listen to the song bc ive liked bts's other songs before
i don't want my eyebrows or head shaved lol
Explanation:
Hi,
Which drug should be administered ?
Answer:
Adenosine 6 mg
Answer: Difference between presumptive test and confirmation test
Explanation:
A presumption test or screening is a test to detect diseases in early stages and shows the prevalence of a disease in the population, it is performed in asymptomatic people, which is classified as having or not having the disease that is sought, the objective of these tests are to reduce morbidity-mortality in the study population, confirmatory tests or diagnostic tests are those that confirm or rule out the disease and are performed after a screening test, an example is HIV-AIDS tests, in which the screening test is performed on the population with risky sexual contacts called the rapid test, ELISA and if it is positive, the Western Blot confirmation test is performed.
