Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
Answer: See explanation
Explanation:
Journal entry simply has to do with the recording of transactions in an accounting book which signifies the debit and credit balances of the company.
For the adjusting entries:
On Dec 31:
Interest expense:
= 16000 × 9% × 11/12
= 1320
Prepaid insurance
= 4400/24 × 9
= 1650
Check the attached file for further explanation.
Answer:
1 plus 1 + 2= 8 ur welcome ;]
Explanation:
1. homeostasis
2. negative feedback loop
3. the hypothalamus
4. the body’s optimal temperature, which is 37 degrees C, or 98.6 F
5. humans are endothermic, which means they don’t completely rely on their environment for heat, unlike ectothermic organisms such as reptiles. the diagram shows that the brain is in control of the body’s temperature, and that the body can raise its own temperature in its blood.
or something like that, hope this helped
Answer:
The coughing reflex kicks in, only if the epiglottis reflex fails to. If the coughing reflex fails then the Heimlich maneuver may be needed.
