Question

A client who has been diagnosed with breast cancer is to receive chemotherapy with both cisplatin and vincristine. The client asks the nurse why both medications must be given together. The nurse should explain to the client that the combination of 2 chemotherapeutic medications is used for which reason

Answer 1

Suggesting that the addition of vincristine and cisplatin chemotherapy would enhance the therapeutic impact.

What are the reasons for combining these medication?

• Clinical research revealed that a single treatment's efficacy remained subpar, with a mediocre survival rate.
• Vincristine is a popular anti-tumor medication that successfully prevents tubulin polymerization and has an impact on the development of spindle microtubules.
• Additionally, it has been noted to disrupt protein metabolism, decrease RNA polymerase activity, and create lipids for cell membranes.
• Furthermore, cisplatin significantly reduces the rate of DNA replication in tumor cells and obliterates the membrane structure of tumor cells.
• In terms of enhancing patients' quality of life and improving their clinical indicators, the combination of vincristine and cisplatin is a superior strategy with excellent safety that is deserving of clinical promotion and use.

Learn more about chemotherapy here:

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