Question

Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-beta1.

Answer 1

The motor neuron disease amyotrophic lateral sclerosis (ALS) is deadly and progresses very quickly. It is known that astrocyte-related factors have a role in the death and degeneration of motor neurons in ALS. The role of astrocyte in increasing motor neuron protein aggregation, a characteristic clinical feature of ALS, is, however, still completely unknown.

What is ALS in medical terms ?

A uncommon neurological condition called amyotrophic lateral sclerosis (ALS) predominantly affects the nerve cells (neurons) in charge of regulating voluntary muscular activity (those muscles we choose to move).

• There is no single clear cause of sporadic ALS, despite the fact that numerous environmental factors have been connected to the disease. These include pesticides, viruses, radiation, and electromagnetic fields in addition to poisons like beta-methylamino-l-alanine (BMAA), which can be found in processed seafood.

Learn more about ALS here:

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