Question

The reaction of 2-methylcyclohexanone with CH3MgBr followed by neutralization gives two alcohols. These two alcohols are

Answer 1

The reaction of 2-methylcyclohexanone with CH3MgBr followed by neutralization gives two alcohols. These two alcohols are cyclohexanol and ethanol. This reaction involves Grignard reaction.

What is Grignard reaction?

• Alkyl, allyl, vinyl, or aryl-magnesium halides (the Grignard reagent) are added to a carbonyl group in an aldehyde or ketone to produce the Grignard reaction. The creation of carbon-carbon bonds depends on this process.
• An organic halide reacts with magnesium, but it does not undergo a Grignard reaction; instead, it produces a Grignard reagent.
• The carbon bonded to magnesium acts as a nucleophile and targets the electrophilic carbon atom that is present within the polar bond of a carbonyl group because carbon is more electronegative than magnesium.
• Usually, the Grignard reagent is added to the carbonyl through a six-membered ring transition state.

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