Answer:
Sickle cell disease is due to a type of substitution mutation.
Explanation:
Sickle cell disease is a condition that is transmitted from parents to children in an autosomal recessive inheritance pattern. It is due to a mutation that is capable of altering the shape of the erythrocyte, as well as its ability to circulate and carry oxygen.
The mutation that occurs in sickle cell disease is due to an alteration in the β-chain of hemoglobin, caused by the substitution of thymine base by adenine in the DNA that determines it. As a result, valine replaces glutamic acid in the β-chain amino acid sequence, with the consequences described.
- <em>The other options are not correct because </em><u><em>deletion, duplication and translocation </em></u><em>correspond to chromosomal mutations, not responsible for sickle cell disease.</em>
The genes that survive and flourish in a species are the strong ones. Strong genes evolve into the next generation, while weaker ones die.
Answer:
X-linked/Sex-linked recessive inheritance
Explanation:
<em>The most likely mode of inheritance of the trait is an X-linked recessive inheritance.</em>
The sex chromosome of a male is XY while that of a female is XX. The Y chromosome is hypothesized not to carry any allele ordinarily. Hence, a male child only needs to inherit one affected allele to become affected for recessive X-linked traits.
During gamete formation, the sex chromosome of the male segregates into X and Y gametes while that of the female segregates into X and X gametes. During fertilization, the X gamete of the male is usually inherited by the female while one of the X gametes of the female is usually inherited by the male.
<u>Assuming a father is affected for an X-linked recessive trait, the affected X chromosome will be passed to a female child and such a child would be a carrier, rather than being affected since she requires the two X chromosomes to be affected in order to exhibit the trait. </u>
<u>The affected X chromosome is thus passed to her male child according to the law of inheritance of the sex chromosome. Hence, the grandson of the affected man inherits the trait through the daughter of the affected man.</u>
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