yes because exertion of the heart increases and makes you lose weight
"Bad" bacteria because there are also good bacteria that we need in order to live not just healthy, because every person gets sick and we need it for our body. Too much good thing is a bad thing.
Prolong feeling of sadness, loss of interests, angry outbursts, tiredness, sleep disturbances, anxiety, loss of appetite, slowed thinking, feeling of worthlessness, frequent/reoccurring of suicidal thoughts, unexplained physical problems and having a hard time thinking. [These are just a few symptoms]