Enzymes are called Biological catalysts because they diminish the activation energy for reactions. As the activation energy is reduced the rate of reaction is increased.
Many enzymes modify their state when substrates bind and it is known as "Induced fit".
Enzymes are nothing but Protein(Biological molecules). Most of the biological reactions are catalyzed by Protein.
Enzymes improve the rate of synthetic reactions without getting altered forever by the reaction.
For this reason Biological catalyst are needed to be cut and copy segemnte in DNA.
A :-) Sickle cell disease occurs more often among people from parts of the world where malaria is or was common. It is believed that people who carry the sickle cell trait are less likely to have severe forms of malaria.