The answer you are looking for is “Drought”.
* More than 40 proteins and glycoproteins involved in the complement system are synthesized by the liver, macrophages, epithelial cells, they are present in the blood in plasmatic form, membrane, some have an enzymatic activity, regulator or membrane receptorThese are elements of the humoral innate immune response, they fight infections, purify immune complexes and apoptotic bodies.
<span>There are indeed three ways to activate the complement:</span>
Classical pathway: Activated by Immunoglobulins in immune complexes, aggregated Immunoglobulins, DNA, CRP, apoptotic bodies .......it involves nine fractions, starting with C1, then C4, C2, C3, to form a classical C5 convertase, then, activation of C5, C6, C7, C8, C9.
Alternative pathway: activated by polysaccharides (bacterial endotoxin), vascular wall poor in sialic acid, aggregated IgE ...C3b like is the first component in the alternate channel cascade, it will create an amplification loop, and form an alternative C5 convertase.
Lecithin pathway: Activated by mannose, fucose (carbohydrate of microorganisms)The first component is the complex MBL / MASP1 / MASP2: "mannose-binding protein": works according to the same principle as the complex C1 of the classical way (MASP2 cleaves the C4 and the rest of the cascade is equivalent to that of the classical way).
the three ways have the same outcome: A C5 convertase (formed by one of the pathways) cleaves C5 into C5a and C5b: C5b is deposited far from other fractions on the antigenic surface. The fixation of C5b in the cell is followed by that of C6, C7, C8, and C9 (9 molecules of C9): formation of the membrane attack complex (MAC) ==> Death of the cell by osmotic shock
Between 1962 and 1971, the United States Army Corps of Engineers (USACE) channeled the Kissimmee River and created a 30-foot deep, 300-foot wide, 56 mile long drainage canal (C-38). This project converted 44% of the floodplain to pasture, draining approximately 31,000 acres of wetlands. Before channelization, the River was a haven for wildlife, including at least 39 species of fish and 38 species of water birds.
Kissimmee River Restoration began in 1992 and has been the most successful ecosystem restoration initiative to date. By re-channelizing the River to replicate its natural paths, birds and other wildlife responded more quickly than anticipated and demonstrated the resiliency of nature. This success has been used all over the world to justify the value of ecosystem restoration. When Kissimmee River Restoration is completed in 2015, more than 40 square miles of the River-floodplain ecosystem will be restored, including almost 20,000 acres of wetlands and 44 miles of historic river channel.
I think it would be either A or B but I am not sure.... If anything I think I would go with A.
Hope this helps
