To convert factor I (fibrinogen) into a fibrin clot
In general terms, “sex” refers to the biological differences between males and females, such as the genitalia and genetic differences. “Gender” is more difficult to define, but it can refer to the role of a male or female in society, known as a gender role, or an individual's concept of themselves, or gender identity.
Earth's service would be bare. There would no longer be life and all water ways would become dried up due to the intense ultra-violent rays of the sun.
Answer:
The correct insulin pathway is described as under:
2. Binding of insulin to the alpha subunit of the insulin receptor
8. Activation of insulin receptor tyrosine kinase
3. Phosphorylation of IRS proteins
6. Phosphorylation of phosphinositide 3-kinase (PI-3K)
4. Conversion of PIP2 to PIP3
7. Activation of PIP3-dependent protein kinase B (PDK1)
5. Glut4 receptors transported to the cell membrane
Explanation:
The insulin signaling pathway is described as under:
RTK (receptor tyrosine kinases) which is a receptor for insulin is an extracellular receptor but in contrast to other cell surface receptors it is catalytic in nature. In the absence of insulin (ligand), it is monomeric but as soon as it gets activated (activation occurs upon ligand binding), it undergo dimerization. It leads to auto-phosphorylation in it's tyrosine residue which subsequently leads to phosphorylation of tyrosine residue of other receptors. Such hyper-phosphorylated receptor have high affinity with enzyme/molecule like IRS protein which have SH2 domain . IRS down stream activates phosphinositide 3-kinase (PI-3K). This enzyme converts component of animal cell membrane PIP2 into PIP3. PIP3 also remains membrane bound but it has the potential to phosphorylate another enzyme named as PIP3-dependent protein kinase B (PDK1). Further, PDK1 leads to the activation of Akt or PK-B. Akt is a serine-threonine kinase which ultimately leads to the recruitment of Glut4 receptors on cell membrane for uptake of more and more glucose into the cell.
Note: Apart from this Akt also phosphorylates another protein named as FOXO which ultimately causes cell growth, Akt can also phosphorylate BAD protein so as to restrict cell apoptosis or we can say it leads to cell survival, Akt also leads to translation in a cell with the help of mTOR raptor etc.
Answer:
DNA:
Dexoyribonucleic acid is the genetic material of almost all the organisms except some virus. DNA contains deoxyribose sugar that lacks 2'OH group on second carbon. The nitrogenous base pair of DNA are adenine, guanine, thymine and cytosine. DNA cannot acts as an enzyme.
RNA:
Ribonucleic acid is present as genetic material in few viruses only. RNA contains oxyribose sugar that has 2'OH group at second position. The nitrogenous base pair of RNA are adenine, guanine, uracil and cytosine. RNA can acts as any enzyme in biological reactions.
