1. there is natural process of human make up,which if disrupts causes many disabilities. like mutation, as science has achieve many but can not engineer a perfect solution.
2. DNA have a certain pattern which if changed could made a human a liability. like getting genes from a sheep and engineered it in a lion which posses other traits. such causes an imbalance in the ecosystem and disrupting the biome. Loin behaving like sheep and sheep behaving like loin.
"Scientists are not close to knowing the exact processes that took place on the earth which led to the origins of life. They may never know the exact answer because the evidence for this very primitive life has probably been destroyed by the more efficient life which evolved from it.