Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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Answer: The scale ratio of a model represents the proportional ratio of a linear dimension of the model to the same feature of the original. Examples include a 3-dimensional scale model of a building or the scale drawings of the elevations or plans of a building.
Explanation:
Answer:
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Explanation:
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Assuming this DNA strand is fully capable of being mature mRNA (5' m7G cap and PolyA tail), nucleotides lead to an mRNA codon, which is 3 nucleotides per codon. In turn, 1 codon leads to 1 amino acid. However, as a single strand, it must be capable of terminating translation, which always requires a stop codon, and thus 3 nucleotides. Hence, we must subtract this from the total amount of codons <em>first</em>.
Hence, only 11 amino acids will be coded by a single DNA strand 36 ncltd long.
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I believe the correct answer is DDT.
It kills mosquitoes but thins the eggs of birds.
Hope this helps.
I think it’s C because if you’re allergic to one cillian than you’re allergic to all of them
Sorry if this is wrong
