<span>You are likely talking about aerobic respiration rather then just glycolysis based on the options: The third option seems best, pyruvate is heavily oxidized during the Kreb's cycle and removed as CO2.
Wrong options
Option1- FADH2 is also another highly energetic molecule produced during
Option2- oxidation of pyruvate is a highly directional process and can be considered irreversible in the cell
Option4- Aerobic respiration RELEASES energy from pyruvate and the into NADH/FADH which is then captured by the electron transport chain. An exergonic rxn would take in energy and would not happen spontaneously
This can be looked from different perspectives, but let me know if my answer made sense. </span>
