Answer:
Because natural selection selects for it. Thus it persists.
Explanation:
You have to understand heterozygote advantage. Basically, it's where heterozygotes have an advantage over homozygotes. In the case of sickle cell disease, heterozygotes have an advantage, and natural selection favors whatever is advantageous. Thus, because heterozygotes each have one recessive sickle-cell allele, as natural selection favors the heterozygotes, the recessive sickle-cell allele persists and remains in the gene pool.
Only once because the DNA replication initiation is tightly linked to cell cycle progression,ensuring that replication occur only once per cycle
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