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Gnoma [55]
3 years ago
14

Chronic myeloid leukemia (CML) is a genetic disorder associated with the Philadelphia chromosome. The Philadelphia chromosome is

a mutation in chromosome 22. Part of chromosome 22 is exchanged with part of chromosome 9, bringing together two genes on chromosome 22 and causing a malignancy. What type of mutation occurs in the Philadelphia chromosome?
Biology
2 answers:
Natalija [7]3 years ago
6 0
The mutation in Philadelphia chromosome is a translocation, identified as, t(9;22)(q34;q11). This abnormal chromosome has a fusion gene, consisting of the ABL gene and the BCR gene, producing the BCR-ABL oncogene. This oncogene produces an enzyme that has a constitutive, abnormal tyrosine kinase activity. The existence of this fusion gene is necessary and sufficient for the generation of leukemia.
raketka [301]3 years ago
6 0

The type of mutation that occurs in the Philadelphia chromosome is translocation.

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