Answer:
because that is where they were founded
Capote describes the rural city as a sleepy near-knit community. They visit a church and they're tremendously free of crime. The friends consider every other's and doors frequently stay unlocked at night time. This experience of assurance, calm, and belief makes Holcomb appealing to criminals.
The acquaintances consider every different's and doors often continue to be unlocked at night time. This experience of assurance, calm, and trust makes Holcomb appealing to criminals. no one expects crime, specifically a crime of such severity.
In case you grew up in a small town or have even actually visited one, you may be capable to narrate the outline of Holcomb in In cold Blood. The 1966 Truman Capote book takes the region within the city of Holcomb, Kansas. during the tale, Capote paints a vivid photograph of Holcomb. In fact, the very first sentence within the ebook is set by Holcomb. We study: ''The village of Holcomb stands on the excessive wheat plains of western Kansas, a lonesome location that different Kansans name 'out there.''' In other words, Holcomb is now removed from the rest of the country, and even those who stay close by see it as a lonely city.
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The unit for power in electricity should be watt. The power show how many energy transferred during a time and the SI unit would be joule per second.
The bill is charging for the amount of energy. The energy could be calculated by multiplying the power with time. In this case, the power in kilo watt will be multiplied by the duration in hour which make the kilowatt hour.
Answer:
by designing a drug with steric effects on BCR-ABL1
Explanation:
Chronic myeloid leukemia (CML) is a type of cancer that affects the bone marrow and blood cells. CML is characterized by the formation of the Philadelphia chromosome, a product of a reciprocal translocation between chromosomes 9 and 22. As a consequence of this translocation, an oncoprotein tyrosine kinase called BCR-ABL1 is formed. This protein (BCR-ABL1) is responsible for 95% of all CMLs. In this case, it is possible to inhibit BCR-ABL1 (and thus inhibit CML cell proliferation) by using a kinase inhibitor. Kinase inhibitors are drugs that inhibit kinase function by preferentially binding to the inactive conformation of the target enzyme. These proteins are used to treat cancer by blocking a functional site on the kinase, thereby inhibiting its function. Moreover, it is known that steric effects alter the mode and rate by which a drug interacts with a given target. In this case, a small molecule with steric effects on BCR-ABL1, i.e., capable of altering the shape (conformation) and reactivity of BCR-ABL1, might also be used to selectively inhibit BCR-ABL1.
First question: ans= D
second question: ans=A
