The theory of evolution is a shortened form of the term “theory of evolution by natural selection,” which was proposed by Charles Darwin and Alfred Russel Wallace in the nineteenth century
Answer:
<u>Cilia</u>
Explanation:
Cilia and flagellum are made up of microtubules.
Cytoskeletal filaments are structures which allow movement. In cilia and flagella, the cytoskeletal filaments are present in the form of microtubules and the primary work of these structures is to facilitate in movement.
Cilia is also present in mammals to facilitate the movement of fluids in cells.
Structurally, there is no difference between cilia and flagella. The only difference between cilia and flagella is in their lengths.
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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Answer:
A
Explanation:
These three phosphate groups are linked to one another by two high-energy bonds called phosphoanhydride bonds. When one phosphate group is removed by breaking a phosphoanhydride bond in a process called hydrolysis, energy is released, and ATP is converted to adenosine diphosphate (ADP).
Answer:
Hemoglobin rainier differ from normal hemoglobin with respect to oxygen affinity.
Explanation:
Hemoglobin is one of the most significant protein of Red Blood Cell containing heme(that contain Fe2+ which is coordinated with four porphyrine rings) and globin protein.
Hemoglobin exist in two state one is tensed state or deoxy hemoglobin that have less affinity for oxygen, the other state is relaxed state or oxy hemoglobin that has high affinity for oxygen.
In hemoglobin rainer the formation of new di sulfide bond prevent the formation of ion pairs that normally stabilize the T state as a result T state get unstable and this unstable T state is converted to R state to achieve the stability of hemoglobin structure.
The R or relaxed state of hemoglobin has high oxygen affinity for oxygen.
