Answer:
The main function of the RB protein is to inhibit the transition from the G1 to S phase. Its activity depends on its phosphorylation state: if RB is not phosphorylated (active state), it is bound to the transcription factor E2F, preventing its translocation to the nucleus and the activation of genes necessary for DNA synthesis; and if it is phosphorylated, by cyclin-CDK complexes, E2F is released and cell proliferation occurs.
Explanation:
Retinoblastoma (Rb) was the first tumor suppressor described and, as we know today, mutations in its structure determine a large number of cancers. Structurally, we speak of a large and multifunctional protein; which is organized in different domains. The activity of this protein is regulated, mainly, by phosphorylation at multiple sites described over the years and is involved in control mechanisms of the cell cycle, apoptosis and senescence.
<span>The answer to this question would be Receipt of breach notice.
In case of a data breach, the provider of the healtcare should inform the patient about what information breached and who might breach it. The provider that failed to do this can get some punishment like locking the electronic system.</span>
Darwin lived in a time where natural selection was a strange theory among scientists and researchers. This was especially true when other researcher Lamarck argued that organisms passed on helpful traits to their offspring, that they magically could form a new trait to adapt to their environment and then pass it onto their offspring. For example, if a giraffe was too short to reach food, it would grow a larger neck in its lifetime and then pass that trait onto its offspring. Darwin argued that, through the process of survival of the fittest, that short giraffe would die off and never receive the chance to pass on its shortness to future populations. Thus, taller giraffes would survive— they can reach food, shorter giraffes can’t— and the short genes would disappear. The fact that Darwin was introducing a new theory that nobody was used to at the time was peculiar, so he had few people on his side until long after his observations.
Another problem Darwin had was the lack of technology. To travel, Darwin would have to use boats to reach far away places, and of course, this took time.
The final problem Darwin had was the extra time it took for evolution, a process that can take up to millions of years. Evolution didn’t occur over night— it took time for Darwin to conduct experiments, observe, conduct them again, come to a conclusion, and so on.
Hope this helped a little!
Answer:
Concerts, sports games, and political rallies can have very large crowds. When you attend one of these events, you may know only the people you came with. Yet you may experience a feeling of connection to the group. You are one of the crowd. You cheer and applaud when everyone else does. You boo and yell alongside them. You move out of the way when someone needs to get by, and you say “excuse me” when you need to leave. You know how to behave in this kind of crowd.
It can be a very different experience if you are travelling in a foreign country and find yourself in a crowd moving down the street. You may have trouble figuring out what is happening. Is the crowd just the usual morning rush, or is it a political protest of some kind? Perhaps there was some sort of accident or disaster. Is it safe in this crowd, or should you try to extract yourself? How can you find out what is going on? Although you are in it, you may not feel like you are part of this crowd. You may not know what to do or how to behave.
Explanation:
I don't have enough knowledge about this hope it helps
Answer:
I cant understand this question. Can u help?
Explanation:
