<span>A drug used to treat CML, imatinib, binds to the active site of Abl kinase. Why does this drug work to treat this type of cancer?
</span><span>B) By binding to the active site, the drug prevents the ability of Abl kinase to bind to its substrate.
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Imatinib works against CML by binding close to the ATP binding site of bcr-abl. The binding results to the<span> locking in of the bcr-abl to a closed or self-inhibited conformation and inhibiting the enzyme activity of the protein </span><span>semi-competitively.</span>
1.Tyrannosaurus Rex Lived in the Mesozoic Era
2.The largest mass extinction happened in the Paleozoic Era
3.Life exploded for the first time in the Precambrian Era
4.The Chicxulub crater in the Cenozoic Era
The northern hemisphere is warmer in the summer than the winter because the northern hemisphere are pointing toward the sun. Because of this the rays hit us more directly making is hotter. So during the winter when the northern hemisphere is not pointing toward us, it makes is colder. It also depends on the tilt of the axis. When it is more direct it makes the temperature hotter.
