Human evolution known to be a process in which species adapt to certain conditions of life, and in the battle of life and death, they are forced to become stronger in order to survive in this world. Diseases have always been present during the evolution, acting themselves as a natural selectors - the weaker organisms get sick and die. Not just humans, but all species have to establish a great protecting mechanism in order to survive. That is how our bodies are built, to be able to withstand and survive in the conditions we live in, and that is why our immune system has to be taken care of.
Fertilizers can make their way into water sources when it rains and when the fertilizer makes it into a lake, the harsh chemicals from the fertilizer will pollute the water.
The mature stage. I hope this was helpful.
You can google it at www.google.com