The overload principle is defined as working harder as the body essentially grows fitter. This is to stimulate muscle hypertrophy against resistance as well as overall cardiovascular health. For instance, an experienced body builder should lift more weight up up to failure to grow even fitter.
If the DNA polymerase did nothing special when a mispairing occurred between an incoming deoxyribonucleoside triphosphate and the DNA template, the wrong nucleotide would often be incorporated into the new DNA chain, producing frequent mutations. The high fidelity of DNA replication, however, depends not only on complementary base-pairing but also on several “proofreading” mechanisms that act sequentially to correct any initial mispairing that might have occurred.
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False is your answer have a good day :)