Disruption of axonal transport would be a good target for his drug.
<h3>What is disruption of axonal transport?</h3>
- Axonal transport defects are among the early molecular events leading to neurodegeneration in mouse models of amyotrophic lateral sclerosis (ALS).
- Gene expression profiles indicate that dynactin-1 mRNA is downregulated in degenerating spinal motor neurons of autopsied patients with sporadic ALS.
- Disruption of axonal transport also underlies the pathogenesis of spinal muscular atrophy and hereditary spastic paraplegias.
- The neurotoxin β,β′-iminodipropionitrile (IDPN) selectively disrupts slow axonal transport without affecting fast anterograde or retrograde axonal transport.
- Impairment of slow axonal transport causes a proximal accumulation of neurofilaments.
- Because neurofilaments regulate axonal diameter, this accumulation leads to a marked swelling of the axon.
- Acrylamide causes decreased axonal transport, also causing proximal accumulations of neurofilaments and swelling.
To learn more about axonal transport,
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Explanation:
in the human body or in general sweetie?
Answer:
Scientific Name
Explanation:
Scientists use a two-namesystem called a Binomial Naming System.
They name animals and plants using the system that describes the genus and species of the organism.
Answer:
The given statements have been rearranged in the following order to depict the flow of events that account for lipid digestion in the human body:
- Mechanical digestion by chewing breaks food down.
- During digestion, gastric lipases break down fat into fatty acids and triglyceride molecules.
- Gastric lipase digests some triglycerides.
- The pancreas secretes gastric lipase into the small intestine, where the majority of fat digestion occurs.
- Lipid digesting enzymes from the pancreas break down the triglycerides into two free fatty acids and a monoglyceride.
- Lingual lipase is secreted from the pancreas and breaks down triglycerides.
- With the aid of pancreatic lipase, fats are further broken down into free fatty acids and monoglycerides.
- Products of fat digestion are packaged into micelles and transported to the enterocytes.
The process is started in the mouth. Action of the teeth physically breaks down the food and increases it surface area that allows for better access to it for the enzymes to carry out mechanical digestion. Gastric lipases are those in the stomach, most of the lipid digestion takes place in the small intestine with the help of enzymes secreted by the pancreas and the small intestine itself. After digestion, the final products are taken up by the lymphatic system.
Hope that answers the question, have a great day!
Hope this image helps you Joshua!! Good Luck!
