Answer:
'Cross experiments done by Morgan, illustrating the X-inheritance link of a mutation Thomas Hunt Morgan moved intensely in a program of breeding and crossing miles of fruit flies at New York University in a room that was renamed the Fourth of the Flies. He tried to mutate the flies with various means (X-rays, centrifuges, etc.) .The fruit fly which has 4 pairs of chromosomes. One of those pairs was identified as containing X and Y sex chromosomes. He applied Mendelian principles in flies. Morgan's inheritance study demonstrated inheritance linked to sex, and is one of the first evidences that confirm the chromosomal theory of cross-based inheritance. In 1909, Morgan detected a fruit fly (Drosophila melanogaster) with a strange mutation which he called "white eyes", due to the coloration of his eyes (contrary to normal, which is red). Analyzing this fly under the microscope Morgan discovered that it was a male, and could use it as a stallion so that he could observe how the new characteristic of white eyes would pass from generation to generation.All the offspring of this cross will have red eyes, which He made Morgan suspect that something strange had happened, since the color of the father's eyes could not have disappeared. He decided to take a couple of "daughters flies" and cross them together, just to see what happened. Morgan's surprise was very great, observing that among the "granddaughters" flies only males had white eyes. The problem then was to explain what had happened during the hereditary transmission for the color of the white eyes only the males possessed. .
They concluded that horses evolved with the emergence of grasslands and an increase of predators. The digits of their early Eocene ancestor evolved into hooves.
A single cell RNA seq analysis identifies 25 population of epidermal cells .
<h3>What is single cell transcriptomics used for?</h3>
Single cell transcriptomics are being used to create reference maps of healthy human tissues, organs and systems at single cell resolution.
An essential model system for studying stem cells and tissue regeneration is the mouse epidermis with its hair follicles. To demonstrate how the cellular heterogeneity of the murine telogen epidermis is controlled at the transcriptional level, we used single-cell RNA-sequencing in this study. 25 different populations of interfollicular and follicular epidermal cells were identified by impartial clustering of 1,422 single-cell transcriptomes. With previously unheard-of resolution, our data allowed for the reconstruction of gene expression patterns during epidermal development and along the proximal-distal axis of the hair follicle.
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