Lethal alleles cause the death of an organism prenatal or after the birth. Lethal alleles are usually a consequence of a mutation and they can be recessive, dominant or conditional. Since the lethal dominant alleles are harmful whether they are carried in homozygous (e.g.AA) or heterozygous (e.g.Aa) form, a strong selection against them is present and thus these alleles are much more rare.
Aerobic respiration to lactic acid fermentation, lactic acid is the reason your muscles get sore after a workout
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Microbes. Bacteria, for example, convert nitrogen and carbon dioxide from the air into usable components that plants and animals can use as essential building blocks. A loss of all microbes would be terrible news for living organisms that can't create or take in these essential nutrients on their own.