Answer:
The symptoms involved in ontogenesis imperfect are- bone breakage, pain in bone, deformation of bones, brittle teeth, coloured tint in the white portion of eyes, loss in hearing and loose joints.
Explanation:
In the disease, ontogenesis imperfect, the strong bone formation in body is prevented by the defective gene that produces collagen protein. People who have the deficiency of collagen by birth, can develop this disease or can have it by birth. This defect can be hereditary.
The symptoms included in this disease are the- deformation and breakage of bones, pain in bone, grey or purple tint in the white portion of the eye, short stature, brittle teeth, hearing impairment and loose joints.
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At the onset of a muscle contraction, the presence of calcium triggers the opening of the Na-K channels in the membrane. Potassium is a calcium inhibitor, so as the potassium flows out of the cell, it eventually reduces the presence of calcium. This causes the closure of the Na-K channel (negative feedback mechanism). In a hypokalemic state, the lack of sufficient K doesn't inhibit the calcium channel, and in turn doesn't properly terminate the muscle contraction at the cellular level.
