Answer:
Multiple sclerosis (MS) is the most common demyelinating and an autoimmune disease of the central nervous system characterized by immune-mediated myelin and axonal damage, and chronic axonal loss attributable to the absence of myelin sheaths. T cell subsets (Th1, Th2, Th17, CD8+, NKT, CD4+CD25+ T regulatory cells) and B cells are involved in this disorder, thus new MS therapies seek damage prevention by resetting multiple components of the immune system. The currently approved therapies are immunoregulatory and reduce the number and rate of lesion formation but are only partially effective. This review summarizes current understanding of the processes at issue: myelination, demyelination and remyelination—with emphasis upon myelin composition/architecture and oligodendrocyte maturation and differentiation. The translational options target oligodendrocyte protection and myelin repair in animal models and assess their relevance in human. Remyelination may be enhanced by signals that promote myelin formation and repair. The crucial question of why remyelination fails is approached is several ways by examining the role in remyelination of available MS medications and avenues being actively pursued to promote remyelination including: (i) cytokine-based immune-intervention (targeting calpain inhibition), (ii) antigen-based immunomodulation (targeting glycolipid-reactive iNKT cells and sphingoid mediated inflammation) and (iii) recombinant monoclonal antibodies-induced remyelination.Keywords: calpain, central nervous system, demyelination, fingolimod, glycolipids, lipids, multiple sclerosis, myelin, myelination, NKT cells, oligodendrocytes, remyelination, T cells
Explanation:
Answer:
this not the straghtest answer i have said but it is it looks like the difference in the two layer on the plant and the animal does not
Explanation:
i did this stuff in the 6th grade so it might be right
Hypnotic is your answer, ypnotic drugs induce sleep and are used to treat insomnia. Insomnia is a change to the normal sleep pattern, due to difficulty in either getting to sleep or maintaining sleep.
An unintentional injury is an accident.
While an intentional injury is when you harm yourself or others on purpose.
Unintentional
A girl falls and scrapes her knee during soccer.
Jake sprained his ankle during practice
Intentional
A boy decides to cut himself
Noel broke her arm so that she wouldnt have to go to school.
