Answer:
Gaucher disease is caused by a deficiency in the enzyme glucocerebrosidase, whose function is to break the glucocerebrosides (type of fat that can be found in the cell membranes) within the cell, which its accumulate cause damage to various organs.
Explanation:
Gaucher disease is the most common of lysossomal storage disease. It's a progressive and genetic disease. It is related to the metabolism of sphingolipids, which are normal components of lipids in cell membranes; they accumulate in lysosomes and cause neuronal, bone, and other extensive changes.
In the absence of this enzyme, there is an accumulation of a particle called glycosylceramide (or GL1). It's a kind of "garbage" that, swells up certain blood cells - macrophages. In this state, they lose their function and got accumulate in places such as the liver, spleen and bone marrow.
Answer:
hehe thanks for saying that
Explanation:
any way thanks for the points
Answer:
Explanation:
The overload principle is one of the seven big laws of fitness and training. Simply put, it says that you have to increase the intensity, duration, type, or time of a workout progressively in order to see adaptations. The adaptations are improvements in endurance, strength, or muscle size.
In other words, when a client first starts working out, from having been previously mostly sedentary, they will see some quick gains. But, as they get fitter, you will need to increase the intensity of their training to continue to see those gains. If they continue lifting the same weights for the same number of sets and reps, week after week, the body will have adjusted to the stress, there will be no more adaptations and they will plateau.
