*A condition that causes a lack of appetite, such as cancer, liver disease, persistent pain or nausea....
*A mental health condition, such as depression or schizophenia, which may affect your ability to look after yourself.
The answer should probably be no if this is an assignment. But if not, you only live once, right? ;p
How much you gained to how much you lost
The only one that would make sense not doing is breathing in slowly because you want the medicine to go in quickly to the airways and not get stuck in your mouth.