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Answer:
Cells that support viral replication are called permissive. Infections of permissive cells are usually productive because infectious progeny virus is produced. Most productive infections are called cytocidal (cytolytic) because they kill the host cell. Infections of nonpermissive cells yield no infectious progeny virus and are called abortive. When the complete repertoire of virus genes necessary for virus replication is not transcribed and translated into functional products the infection is referred to as restrictive. In persistent and in some transforming infections, viral nucleic acid may remain in specific host cells indefinitely; progeny virus may or may not be produced.
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Answer: Different types of drugs affect your body in different ways, and the effects associated with drugs can vary from person to person. How a drug effects an individual is dependent on a variety of factors including body size, general health, the amount and strength of the drug, and whether any other drugs are in the system at the same time. It is important to remember that illegal drugs are not controlled substances, and therefore the quality and strength may differ from one batch to another
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Drug-drug interactions (DDIs) are one of the commonest causes of medication error in developed countries, particularly in the elderly due to poly-therapy, with a prevalence of 20-40%. In particular, poly-therapy increases the complexity of therapeutic management and thereby the risk of clinically important DDIs, which can both induce the development of adverse drug reactions or reduce the clinical efficacy. DDIs can be classify into two main groups: pharmacokinetic and pharmacodynamic. In this review, using Medline, PubMed, Embase, Cochrane library and Reference lists we searched articles published until June 30 2012, and we described the mechanism of pharmacokinetic DDIs focusing the interest on their clinical implications.
Keywords: Absorption, adverse drug reaction, distribution, drug-drug interactions, excretion, metabolism, poly-therapy
