Clotting will end up being an issue. The cells inside of the arterial wall are being blockaded by the deposit, therefor regular blood flow cannot circulate as its supposed to.
That would be the nervous system.
The regular recommendation of many health professionals are to drink 8-10 glasses of water daily however, this is dependent on the activity the person is engaging in and the climate the person is engrossed to. For example, when an athlete has ran possibly n kms. it might be a necessity for a person to drink water since the body processed much faster than normal.
The answer is A) Skin color. Hope this helps!:)