Question

For a drug that has an initial plasma concentration of 120 mg/L and a half-life of 3 hours, what would the plasma concentration be 12 hours after the initial concentration of the drug elimination is following first order elimination?

Answer 1

Answer:

7.5 mg/L

Explanation:

As the drug elimination is following the first order of reaction mechanism so for such reactions the following equation relates the final and initial amount

$\text {Final amount} = \text {initial amount}(\frac{1}{2} )^{\frac{t}{\text {half life}} }$

The values given in the question are

Initial concentration = 120 mg/L

Half life = 3 hours.

Time = 12 hours

Thus, putting the given values in the above equation, we get

$\text {Final amount}= 120(\frac{1}{2} )^{\frac{12}{3} }$$= 120(\frac{1}{2} )^{4 } = \frac{120}{16} = 7.5$

Thus, after 12 hours the concentration of the remaining drug will be 7.5 mg/L.