Tight-fitting respirators must seal to the wearer’s face in order to provide expected protection. This includes disposable respirators (also called “filtering facepieces”). Therefore, fit testing is required in the US by the Occupational Safety and Health Administration (OSHA) before a user wears a mandatory respirator on the job, and must be assessed at least annually. In addition, fit tests should be performed:
Whenever a different size, style, model or make of respirator is used.
When any facial changes occur that could affect fit, such as significant weight fluctuation or dental work.
A good fit means the respirator will seal to your skin. A respirator can only work when air passes through the filter. Air will take the path of least resistance, so if the seal isn’t there, the air will go around rather than through the respirator – and therefore lessen the protection.
Safety glasses, hearing protection, face shields, hard hats and coveralls can all vie with a respirator for real estate on a person’s face, head or body. For instance, if a half face respirator doesn’t fit well (especially if it’s too large), it can overlap with glasses. The more that happens, the more fogging can potentially occur on glasses, and the more likely it is that they’ll interfere with the respirator’s seal.
<span>Since alkylating agents work to prevent the cell from replicating its genetic material, the cell would most likely stop at the interphase checkpoint, which is the phase before mitosis (which consists of prophase, metaphase, anaphase, and telophase). During interphase, the cell replicates its genetic material (DNA), but this would be prohibited by alkylating agents.</span>
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