The Monroe Doctrine was a policy by James Monroe basically warning European countries from attempting to further colonize the Western Hemisphere. Not to mention, it failed.
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The regions are the Coastal Plain, the Piedmont Region, the Blue Ridge Region, the Valley and Ridge Region, and the Appalachian Plateau.
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The large political upheaval (Articles of Confederation to Constitutional Convention and United States Constitution, Bill of Rights)
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From 3100 BC to 400 BC Ancient Egypt was a successful center of civilization.
Explanation:
Ancient Egypt was a civilization that developed along the middle and lower reaches of the Nile from about 3150 BC until it was conquered by Alexander the Great in 332 BC. It extended south from the Nile estuary to Jebel Barkal near the fourth cataract.
Egyptian civilization depended on the River Nile. When the rains further south caused the river to overtop its banks and cover much of the land, it would immediately irrigate and fertilize the land. This was of great importance in a country where there is virtually no rain.