Tricyclic antidepressant (TCAs) class is most closely linked with anticholinergic side effects.
Amitriptyline, amoxapine, clomipramine and protriptyline are Tricyclic antidepressants (TCAs) that are used to treat chronic pain. Amitriptyline and nortriptyline among these medications provide the most reassuring safety information during pregnancy and breastfeeding.
In vitro and in vivo, TCAs are powerful inhibitors of norepinephrine and/or serotonin reuptake. In addition, several TCAs are known to block sodium, calcium, alpha-1 adrenoceptors, histamine (H1) receptors, and muscarinic cholinergic receptors. Thought to be responsible for their unfavourable anticholinergic, antihistaminergic, and cardiotoxic side effects rather than their antidepressant effects, these neurotransmitter receptor actions.
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People who have opposite personality traits such as aggressiveness, stubbornness, inflexibility, and tenseness are <span>people who typically do not live as long as the average life expectancy. This might due to the negative environment he or she has.</span>
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The action or process of making ready or being made ready for use or consideration.
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