A is the answer hope this helps
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<span>Lafora disease is the most severe teenage-onset progressive epilepsy, a unique form of glycogenosis with perikaryal accumulation of an abnormal form of glycogen, and a neurodegenerative disorder exhibiting an unusual generalized organellar disintegration. The disease is caused by mutations of the EPM2A gene, which encodes two isoforms of the laforin protein tyrosine phosphatase, having alternate carboxyl termini, one localized in the cytoplasm (endoplasmic reticulum) and the other in the nucleus. To date, all documented disease mutations, including the knockout mouse model deletion, have been in the segment of the protein common to both isoforms. It is therefore not known whether dysfunction of the cytoplasmic, nuclear, or both isoforms leads to the disease. In the present work, we identify six novel mutations, one of which, c.950insT (Q319fs), is the first mutation specific to the cytoplasmic laforin isoform, implicating this isoform in disease pathogenesis. To confirm this mutation's deleterious effect on laforin, we studied the resultant protein's subcellular localization and function and show a drastic reduction in its phosphatase activity, despite maintenance of its location at the endoplasmic reticulum.
I got my information from </span>https://www.ncbi.nlm.nih.gov/pubmed/14722920
It can never be created or destoryed because it goes from form to form. For example electric energy helps start ovens that are electric, or chemical energy helps cars get into motion. Radiation energy helps give trees life, the sun helps give trees life.
Answer:
C) From the Golgi apparatus and the rough ER to the cytoplasm and the mitochondria.
Explanation:
The protiens synthesized by the cells move through the endomembrane system and are released from the trans face of the golgi apparatus in the transport vesicles that move through the cytoplasm and ultimately fuse with the plasma membrane resulting in the release of the protien to the outside of the cell.
Hence option C) From the Golgi apparatus and the rough ER to the cytoplasm and the mitochondria. is the right answer.