Human monoclonal antibody (mAbs) are emerging in the field of cancer therapy and have become an increasing proportion of new drugs that are recently approved. Although there are some methods to obtain antigen-specific mAbs from human B cells, it is generally impossible to directly immunize human beings with antigens of interest. For example, for infectious agents, those approaches are largely restricted. To solve these obstacles, two main approaches have been developed; either by humanizing antigen-specific antibodies from small experimental animals (which is laborious due to the great genetic differences from humans) or rely on the in vitro selection of antigen-specific binders from human antibody repertoires. However, the human mAbs developed by these methods are usually with low affinity.
We are now coming up with a much better idea that is humanizing non-human primates mAbs instead of murine mAbs. Due to the close genetic relationship with humans, immunized NHPs have more potential to be isolated with high affinity antibody to human target than other experimental species, such as mouse, rat and rabbit. In addition, with appropriate method, NHP antibodies are much<span> easier to be humanized</span> without any loss of affinity compared to widely used murine antibodies.
Resource: http://www.creative-biolabs.com/High-Affi-TM-Human-Antibody-Discovery.html
Answer;
The client had six drinks a few hours ago.
Explanation;
-Disulfiram is used to treat chronic alcoholism. It causes unpleasant effects when even small amounts of alcohol are consumed.
-The drug can stay in the body for up to two weeks and can make patients feel sick any time they consume alcohol during that period. In fact, alcohol ingestion has been known to produce the same unpleasant effects 1-2 weeks after a person has taken her last dose of disulfiram.
An onion cell has a rectangular shape
Answer:
The population would decrease because of competition between the organisms.
Explanation:
the population would decrease because there eventually wouldn't be enough resources to support the population.
The answer is sensations. Sensation alludes to the way toward detecting our condition through touch, taste, sight, sound, and smell. This data is sent to our brains in crude frame where discernment becomes possibly the most important factor. Discernment is the way we decipher these sensations and hence comprehend everything around us.
