Answer:
CFTR protein facilitates the transport of chloride ions and water across the cells. Genetic defect in the CFTR gene results in defective protein synthesis. This defect in CFTR protein disrupts the chloride and water channel across the cell. The CFTR protein acts as a channel across the cell membranes which are specialized to produce mucus, sweat, tears etc. Failure of transport channel will result in symptoms like secretion of thick mucus. This mucus can obstruct the airflow and glands resulting in symptoms of cystic fibrosis.
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The addition of acetyl groups to histones leads to a weaker association of DNA in nucleosomes because they help to condense it into chromatin.
<h3>What is the relationship between histones and DNA?</h3>
Histones are a family of basic proteins that associate with DNA in the nucleus and help to condense it into chromatin. Nuclear DNA does not appear on free linear strands; it is highly condensed and involves histones to fit inside the nucleus and participate in the formation of chromosomes.
<h3>How does DNA compact with histones?</h3>
Each chromosome is made up of a single molecule of double-stranded DNA wrapped around histones, the nucleosome. This fiber rewinds into a second level of compression, known as the solenoid. Most of the time, cells keep the DNA compacted in the selenoid loops attached to the chromosomal backbone.
Whit this information, we can conclude that the addition of acetyl groups to histones leads to a weaker association of DNA in nucleosomes because they help to condense it into chromatin.
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