Question

If negative selection of T-lymphoctyes in the thymus never occurred, what would likely happen? The specificity of the immune system would improve. T-lymphocytes would bind self-antigens. Mature T-lymphocytes would lack CD proteins. T-lymphocytes would be unable to bind nonself-antigens.

Answer 1

Answer:

The correct answer would be "T-lymphocytes would bind self-antigens".

Negative selection of T-lymphocytes takes place in the cortico-medullary junction in the thymus.

It removes T-lymphocytes which show high-affinity binding with self-antigen. Thus, it helps in introducing self-tolerance in T-lymphocytes.

In absence of negative selection, T-lymphocytes which show high-affinity binding for self-antigen would survive and develop into mature T-lymphocytes.

Consequently, T-lymphocytes would able to bind to self-antigens of the body which can result in autoimmune disease.