The Overload Principle: Recommends that you need to stress in order to improve.
The F.I.T.T. Principle: Is used to help one's achieve fitness goal by working out the frequency of training sessions, intensity of different sessions, duration of sessions and the type of exercise in the session such as strength or endurance.
The Specificity Principle: Sports training should correspond to the sport the individual is training for to reach their desired goal.
The Rest and Recovery Principle: Mentions that people need time to rest and recover after vigorous training sessions.
The Use It or Lose It Principle: Implies that you need to workout certain body muscles if you want to maintain your muscle mass. If you stop working out as often as you used to you will lose muscle mass and it will take a longer period of time for your to build up the muscle mass that you lost.
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Autoantibodies that contribute to the destruction of beta cells contributes to the development of type I diabetes mellitus (DM)
Explanation:
The autoantibodies produced in the cells of the islet of Langerhans in the pancreas are the main contributors of type I diabetes mellitus, which is an autoimmune-mediated disease.
DM type I is caused due to inhibition of insulin secretion by the beta cells of the pancreas. The autoantibodies are produced due to the presence of autoantigens like GAD65 which causes autoimmune pathogenesis of the pancreatic beta cells.
Along with these autoantibodies, the T-cell receptors act as mediators in the destruction of beta cells which finally results in DM.
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