Question

Dexamethasone is a drug that suppresses the secretion of ACTH. If you give Dexamethasone to someone with normal hormone levels, what would happen to his/her levels of CRH and cortisol? What effect would this have on the person’s plasma glucose concentration? Explain your answers. Include in your answer a description of the hormone pathway involved here.

Answer 1

Answer:

Dexamethasone drug in an individual lowers the level of plasma cortisol by lowering the release of Adrenocorticotropic hormone from the anterior lobe of pituitary gland.But in case of people suffering from Cushing syndrome dose of dexamethasone does not lowers the plasma cortisol level.

Explanation:

Dexamethasone is a synthetic Glucocorticoid.As a result it"s functions will be analogous to that of Glucocorticoid.Dexamethasone generally stimulate the rate of Gluconeogenesis thus increasing the production of glucose.As a result the plasma glucose level is elevated.