Answer:
Hepato- and nephrotoxicity of fluoride have been demonstrated in animals, but few studies have examined potential effects in humans. This population-based study examines the relationship between chronic low-level fluoride exposure and kidney and liver function among United States (U.S.) adolescents. This study aimed to evaluate whether greater fluoride exposure is associated with altered kidney and liver parameters among U.S. youth.
This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (2013–2016). We analyzed data from 1983 and 1742 adolescents who had plasma and water fluoride measures respectively and did not have kidney disease. Fluoride was measured in plasma and household tap water. Kidney parameters included estimated glomerular filtration rate (calculated by the original Schwartz formula), serum uric acid, and the urinary albumin to creatinine ratio. Liver parameters were assessed in serum and included alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, blood urea nitrogen, gamma-glutamyl transferase, and albumin. Survey-weighted linear regression examined relationships between fluoride exposure and kidney and liver parameters after covariate adjustment. A Holm-Bonferroni correction accounted for multiple comparisons.
The average age of adolescents was 15.4 years. Median water and plasma fluoride concentrations were 0.48 mg/L and 0.33 μmol/L respectively. A 1 μmol/L increase in plasma fluoride was associated with a 10.36 mL/min/1.73 m2 lower estimated glomerular filtration rate (95% CI: −17.50, −3.22; p = 0.05), a 0.29 mg/dL higher serum uric acid concentration (95% CI: 0.09, 0.50; p = 0.05), and a 1.29 mg/dL lower blood urea nitrogen concentration (95%CI: −1.87, −0.70; p < 0.001). A 1 mg/L increase in water fluoride was associated with a 0.93 mg/dL lower blood urea nitrogen concentration (95% CI: −1.44, −0.42; p = 0.007).
Fluoride exposure may contribute to complex changes in kidney and liver related parameters among U.S. adolescents. As the study is cross-sectional, reverse causality cannot be ruled out; therefore, altered kidney and/or liver function may impact bodily fluoride absorption and metabolic processes.
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rate brainiest
Answer:
A. Lancelet
B. All chordates
Explanation:
A. Dorsal nerve chord is the only <u>unique feature</u> among all members of <u>phylum chordata</u> (mainly found in subphylum Vertebrata). In the given list, only lacelet is the Chordate whereas <u>snail belongs to phylum Mollusca</u>, <u>grasshopper belongs to Arthropda</u>, and <u>jellyfish belongs to Cnidaria</u>. Dorsal nerve cord runs along the length of organism's body.
B. <u>Gill slits</u> are <u>opening structures</u> to gills through which water passes from pharynx/throat to exterior. Their main purpose is to help filter the food particles available in surrounding water. Although they are typical for amphibians and fishes, chordates also possess gill slits at embryonic stages.
Answer:
because when you do it on accident it is unintentional and scares you because you werent expecting it. but when you do it on purpose it wont hurt because your brain stops you from doing it so hard that it hurts lol
Explanation:
Answer:
Electron microscope would be used for if,
C) details of cell structures needed to be distinguished.
Explanation:
- The general principal of electron microscopy is analogous to light microscopy except that it uses electrons to analyse the specimen instead of light.
- Electron microscopy focuses a beam of electron on the target sample and records the difference in absorption by different surfaces.
- Electron microscopy is used to get the detailed structure of cells and surface features of various viruses and bacteria.
- However, it is not possible to view living biological samples through electron microscope because high velocity electron have immense energy to kill living cells.
- These samples are thus, fixed and then viewed.
