Answer:
Through simple diffusion, down the concentration gradient.
Explanation:
The phospholipids of the membrane are amphipathic with hydrophillic heads and hydrophobic tails. Other polar molecules cannot go through this hydrophobic interior. Since small uncharged lipids are non polar and hydrohobic, they are able to go through the membrane without the help of transport proteins. Therefore, the last two options can be ruled out because facilitated diffusion includes the use of a protein. Diffusion involves molecules moving down the concentration gradient so the second option can be ruled out.
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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Answer:
Barbara investigating that which food the ants like the most in order to use this food for killing the ants and removes them from a specific area.
Explanation: Ants are insects which sometimes act as pest because it lives in holes in the house and act as a carrier of many harmful diseases so in order to control the spreading of the disease we have to control the population of ants.
The right answer is C
This process is called anaerobic respiration. It doesn't need dioxygen to occur (it can happen with or without O2).
Anaerobic respiration is a mechanism in which electrons pass through a chain of transporters whose final acceptor is a mineral substance other than oxygen, unlike aerobic respiration where the final acceptor is dioxygen. The final acceptor may be the nitrate ion (as in the case of Pseudomonas), carbon dioxyde or the sulfate ion.
Some bacteria (Pseudomonas) are able, anaerobically, to reduce nitrates to nitrites and then, depending on the case, to dinitrogen (with the enzyme Nitrate reductase A).
NO3- ==> NO2- ==> N2.
Answer:
Protection
Explanation:
The plasma membrane, or the cell membrane, provides protection for a cell. It also provides a fixed environment inside the cell. And that membrane has several different functions. One is to transport nutrients into the cell and also to transport toxic substances out of the cell.