Question

Label each statement below as either describing the limit of detection (LOD) or the limit of quantitation (LOQ

Answer 1

Answer:

It is the minimum amount of analyte that produces a signal which can be measured with reasonable accuracy - LOQ

The concentration is equal to three times the standard deviation of the signal from the blank divided by the slope of the calibration curve - LOD

The concentration is equal to 10 times the standard deviation of the signal from the blank divided by the slope of the calibration curve - LOQ

It is the minimum amount of analyte that produces a signal that is significantly different from the blank - LOD

Explanation:

We define the limit of detection has the lowest amount of analyte that produces a signal that is significantly different from a blank solution ( the absence of the substance). It is calculated as three times the standard deviation of the signal from the blank divided by the slope of the calibration curve.

The limit of quantitation (LOQ) is defined as the minimum amount of analyte that produces a signal which can be measured with reasonable accuracy. It is measured as 10 times the standard deviation of the signal from the blank divided by the slope of the calibration curve.