At the synapse, neurotransmitters bind to neurotransmitter receptors in the postsynaptic neuron’s plasma membrane. This results in the opening of the ions channels and the flow of specific ions to change the voltage across the membrane. An inhibitory neurotransmitter inhibits the firing of the action potential by making the inside of the membrane more negative. It is called hyperpolarization (inhibition).
It may occur when the neurotransmitter opens the Cl– or K+ channels to allow the movement of chloride ions into the cell while permitting the outward movement of potassium ions to make the inside of the cell more negative.
